Recent trends in acute lung injury mortality: 1996–2005*

• DOI: 10.1097/ccm.0b013e31819fefdf
• Publication Date: 2009-05-21T16:28:27Z
• Authors: Sara E. Erickson; Greg S. Martin; J Lucian Davis; Michael A. Matthay; Mark D. Eisner
• Keywords: Adult; Male; Critical Care; Critical Illness; Incidence; Acute Lung Injury; Middle Aged; Combined Modality Therapy; Respiratory Function Tests; 3. Good health; Cohort Studies; Cause of Death; Multivariate Analysis; Humans; Female; Hospital Mortality; Registries; Aged; Follow-Up Studies; Probability; Randomized Controlled Trials as Topic

Objective: Studies from single centers have suggested that mortality acute lung injury (ALI) has declined over time. However, recent trends in ALI across the United States are unknown. We sought to determine whether advances treatment of and related critical illnesses resulted decreased ALI. Design: Retrospective cohort study patients enrolled Acute Respiratory Distress Syndrome (ARDS) Network randomized controlled trials. Setting: Adult intensive care units participating ARDS Patients: 2,451 mechanically ventilated with trials between 1996 2005. Measurements Main Results: Crude was 35% 1996–1997 during each subsequent time period a low 26% 2004–2005 (test for trend p < 0.0005). After adjusting demographic clinical covariates, including receipt lower tidal volume ventilation severity illness, temporal persisted = 0.002). When analyzed by individual causes injury, there were not any statistically significant 60-day most common (pneumonia, sepsis, aspiration, trauma). Conclusions: Over past decade, seems be clear improvement survival among treated at centers. Our findings strongly suggest other advancements care, aside ventilation, accounted this mortality.