Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department*

• DOI: 10.1097/ccm.0b013e3181cc4824
• Publication Date: 2010-03-24T08:12:13Z
• Authors: David F. Gaieski; Mark E. Mikkelsen; Roger A. Band; Jesse M. Pines; Richard Massone; Frances F. Furia; Frances S. Shofer; Munish Goyal
• Keywords: Interquartile range; Triage; Early goal-directed therapy

To study the association between time to antibiotic administration and survival in patients with severe sepsis or septic shock whom early goal-directed therapy was initiated emergency department.Single-center cohort study.The department of an academic tertiary care center from 2005 through 2006.Two hundred sixty-one undergoing therapy.None.Effects different cutoffs triage administration, qualification for appropriate on in-hospital mortality were examined. The mean age 261 59 +/- 16 yrs; 41% female. In-hospital 31%. Median antibiotics 119 mins (interquartile range, 76-192 mins) 42 0-93 mins). There no significant when assessed at hourly cutoffs. When analyzed antibiotics, there a <1 hr (mortality 19.5 vs. 33.2%; odds ratio, 0.30 [95% confidence interval, 0.11-0.83]; p = .02) cutoff; similarly, seen < =1 25.0 38.5%; 0.50 0.27-0.92]; .03) cutoff.Elapsed times antimicrobials are primary determinants treated therapy.