Adverse events and their relation to mortality in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia*

• DOI: 10.1097/ccm.0b013e3181fa4301
• Publication Date: 2010-10-15T07:50:39Z
• Authors: Niklas Nielsen; Kjetil Sunde; Jan Hovdenes; Richard R. Riker; Sten Rubertsson; Pascal Stammet; Fredrik Nilsson; Hans Friberg
• Keywords: Male; Analysis of Variance; Critical Care; Incidence; Hemorrhage; Pneumonia; Middle Aged; Prognosis; 3. Good health; Europe; Intensive Care Units; 03 medical and health sciences; 0302 clinical medicine; Hypothermia, Induced; Cause of Death; Confidence Intervals; Odds Ratio; Humans; Female; Prospective Studies; Registries; Out-of-Hospital Cardiac Arrest; Aged

To investigate the association between adverse events recorded during critical care and mortality in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia.Prospective, observational, registry-based study.Twenty-two hospitals Europe United States.Between October 2004 2008, 765 were included.None.Arrhythmias (7%-14%), pneumonia (48%), metabolic electrolyte disorders (5%-37%), seizures (24%) common period hypothermia, whereas sepsis (4%) bleeding (6%) less frequent. Sustained hyperglycemia (blood glucose >8 mmol/L for >4 hrs; odds ratio 2.3, 95% confidence interval 1.6-3.6, p < .001) anticonvulsants (odds 4.8, 2.9-8.1, associated increased a multivariate model. An frequency of occurred after invasive procedures (coronary angiography, intravascular devices cooling, intra-aortic balloon pump), but not 1.0, 0.46-2.2, = .91, 0.30, 0.12-0.79, .01, respectively).Adverse arrest. mortality. Bleeding infection more procedures, these our study.