Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness*

• DOI: 10.1097/ccm.0b013e3182190b62
• Publication Date: 2011-04-01T09:28:27Z
• Authors: Scott K. Powers; Matthew B. Hudson; W. Bradley Nelson; Erin E. Talbert; Kisuk Min; Hazel H. Szeto; Andreas N. Kavazis; Ashley J. Smuder
• Keywords: Diaphragm (acoustics); Muscle weakness

Mechanical ventilation is a life-saving intervention used to provide adequate pulmonary in patients suffering from respiratory failure. However, prolonged mechanical associated with significant diaphragmatic weakness resulting both myofiber atrophy and contractile dysfunction. Although several signaling pathways contribute diaphragm during ventilation, it established that oxidative stress required for occur. Therefore, identifying the site(s) of ventilation- induced reactive oxygen species production important.These experiments tested hypothesis elevated mitochondrial emission ventilation-induced stress, atrophy, dysfunction diaphragm.Cause effect was determined by preventing rats using novel mitochondria-targeted antioxidant (SS-31).None.Compared mechanically ventilated animals treated saline, SS-31 were protected against dysfunction, protease activation diaphragm. Importantly, treatment also dysfunction.These results reveal prevention increases protects weakness. This important new finding indicates mitochondria are primary source ventilation. These could lead development therapeutic impede