Extravascular lung water is an independent prognostic factor in patients with acute respiratory distress syndrome*

• DOI: 10.1097/ccm.0b013e31826ab377
• Publication Date: 2012-12-20T19:38:17Z
• Authors: Mathieu Jozwiak; Serena Silva; Romain Persichini; Nadia Anguel; David Osman; Christian Richard; Jean-Louis Teboul; Xavier Monnet
• Keywords: Interquartile range

Acute respiratory distress syndrome might be associated with an increase in extravascular lung water index and pulmonary vascular permeability index, which can measured by transpulmonary thermodilution. We tested whether are independent prognostic factors patients acute syndrome.Retrospective study.Medical intensive care unit.Two hundred consecutive (age = 57 ± 17, Simplified Physiology Score II 20, overall day-28 mortality 54%).Extravascular were collected (PiCCO device, Pulsion Medical Systems) at each day of the episode.The maximum values recorded during episode (maximum value respectively) significantly higher nonsurvivors than survivors (mean SD: 24 10 mL/kg vs. 19 7 predicted body weight, p < 0.001 [t-test] for median [interquartile range]: 4.4 [3.3-6.1] 3.5 [2.8-4.4], Wilcoxon's test). In multivariate analyses, or II, blood lactate, mean positive end-expiratory pressure, cumulative fluid balance, minimal ratio arterial oxygen pressure over inspired fraction all independently mortality. A >21 a sensitivity [95% confidence interval]) 54% (44-63)% specificity 73% (63-82)%. The rate was 70% 43% remaining (p 0.0003). >3.8 67% (57-76)% 65% (54-75)%. 69% 37% group ≤ 3.8 0.0001).Extravascular thermodilution risk syndrome.