Impact of lifestyle factors on preneoplastic changes in prophylactic oophorectomies of BRCA mutation carriers.

• DOI: 10.1097/cej.0b013e32834c9b22
• Publication Date: 2012-03-01
• Authors: Helga Primas; Regina Kroiss; Karin Kalteis; Christine Rappaport; Daniela Muhr; Christian Primas; E. Kubista; Reinhard Horvat; Peter J. Oefner; Christian Singer; Teresa Wagner And...
• Keywords: BRCA Mutation

BRCA mutation carriers are at high risk of developing ovarian cancer. Ovarian malignancies usually identified an advanced stage with poor prognosis, attributed to inadequate options early detection. Because its risk-reducing effect nearly 96%, prophylactic salpingo-oophorectomy is still the leading option for risk-reduction in women a positive status. The presence cancer precursor lesions, such as epithelial inclusion cysts (EICs) or cortical invaginations (CIs), has previously been discussed several studies diverse conclusions. We retrospectively investigated large and consistent population (n=94) potential preneoplastic neoplastic changes. also examined role specific lifestyle factors. Ninety-four disease-associated germline BRCA1 BRCA2 mutations were included this retrospective study. All had undergone genetic counseling salpingo-oophorectomy, which was performed mean age 43.33 years (range 27-66). Histological slides both ovaries reviewed by independent pathologist. Data concerning factors collected from medical files questionnaires. Two malignant lesions (2.1%), one bilateral serous papillary adenocarcinoma surface peritoneum involvement left adnexa, lesion (1.1%) obvious potential, mucinous borderline tumor right ovary, have identified. registered prevalence CIs (30; 31.9%) EICs (44; 46.8%) prophylactically removed carriers. A significant correlation (P=0.002) found regard increased BMI. Concerning regular consumption alcohol factor premalignant particular CIs, statistically insignificant trend (P=0.083) noted. Overweight seem be more than normal weight. To improve final outcome disease, should appropriately informed