Clinical evaluation of an autofluorescence diagnostic device for oral cancer detection

• DOI: 10.1097/cej.0b013e32834fdb6d
• Publication Date: 2012-01-04T16:43:24Z
• Authors: Majeed Rana; Antonia Zapf; Marco Kuehle; Nils-Claudius Gel...; André M. Eckardt
• Keywords: Autofluorescence; Gold standard (test)

The prognosis for patients with oral squamous cell carcinoma remains poor despite advances in multimodal treatment concepts. Early diagnosis and is the key to improved patient survival. A device (VELscope) that uses autofluorescence technology, allowing direct fluorescence visualization of cavity, might be a useful tool cancer detection or as an adjunct standard clinical examination. total 289 premalignant lesions were randomly divided into two groups examination precancerous lesions. In group 1, 166 examined conventionally white light, 2, 123 addition light Biopsies obtained from all suspicious areas identified both (n=52). first step, baseline characteristics (only vs. VELscope) compared exclude selection bias. second VELscope (123 patients), diagnostic strategies regard sensitivity specificity using biopsy gold standard. results showed leads higher (100% instead 17%), but lower (74% 97%). Thus, we can conclude new diseases.