The Impact of Tumor Volume and Radiotherapy Dose on Outcome in Previously Irradiated Recurrent Squamous Cell Carcinoma of the Head and Neck Treated With Stereotactic Body Radiation Therapy

• DOI: 10.1097/coc.0b013e3181e84dc0
• Publication Date: 2010-09-21T11:36:10Z
• Authors: Jean-Claude M. Rw...; Dwight E. Heron; Robert L. Ferris; Regiane S. Andrade; Michael K. Gibson; Yong Yang; Cihat Ozhasoglu; Athanassios E. Ar...; Jennifer R. Grandis; Steven A. Burton
• Keywords: Cyberknife

To assess the effect of stereotactic body radiotherapy (SBRT) dose and tumor volume on outcomes in patients with recurrent, previously irradiated squamous cell carcinoma head neck.A total 96 neck were treated SBRT using Cyberknife Trilogy-intensity-modulated radiosurgery. Kaplan-Meier survival analyses used to estimate locoregional control (LRC) overall rates. Response was evaluated positron emission tomography/computed tomography or computed detailed physical examination.The median follow-up for all 14 months (2-39 months). The prior radiation 68.4 Gy (32-170 Gy). Patients divided into 4 groups: I (15-28 Gy/n = 29), II (30-36 22), III (40 18), IV (44-50 27). gross (GTV) 24.3(3) cm (2.5-162 cm). For GTV ≤25 cm(3) (n 50), complete response rates 27.8%/30%/45.5%/45.5%, >25 46), 20%/25%/42.8%/50% groups I-IV, respectively. 1-/2-/3-year LRC doses 40 50 69.4%/57.8%/41.1%, respectively, whereas 15 36 Gy, they 51.9%/31.7%/15.9%, respectively (P 0.02). 1- 2-year 58.9% 28.4%, Treatment well tolerated no grade 4/5 toxicities.Dose escalation up 5 fractions is feasible recurrent carcinoma. Higher associated significantly higher Large required achieve optimal compared smaller volume.