Fractionated Stereotactic Radiosurgery for Large Brain Metastases

• DOI: 10.1097/coc.0b013e31828aadac
• Publication Date: 2013-04-04T09:57:40Z
• Authors: Rodney E. Wegner; Jonathan E. Leeman; Peyman Kabolizadeh; Jean-Claude Rwigema; Arlan H. Mintz; Steven A. Burton; Dwight E. Heron
• Keywords: Adult; Aged, 80 and over; Male; Brain Neoplasms; Kaplan-Meier Estimate; Middle Aged; Radiosurgery; Disease-Free Survival; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Dose Fractionation, Radiation; Aged; Proportional Hazards Models

Objectives: Large brain metastases (>3 cm) present a therapeutic dilemma, as the dose delivered by stereotactic radiosurgery (SRS) in single fraction is limited toxicity to adjacent tissues, resulting suboptimal local control. This study assessed efficacy and safety of fractionated SRS for treatment large metastases. Materials Methods: We identified 36 patients with 37 treated SRS. The median was 24 Gy (range, 12 27 Gy) 2 5 fractions volume 15.6 mL 10 82.7 mL). Kaplan-Meier analysis used estimate control overall survival rates. Results: Of 21 lesions available radiographic follow-up, 6 (29%) had documented failure, yielding an actuarial progression-free at months 73% 63%, respectively. 6-month 1-year rates were 22% 13%, No this cohort experienced acute or late complications secondary Conclusions: Fractionated feasible safe Local appear be improved when compared that relative paucity treatment-related toxicity.