Sebaceous Differentiation in Poroid Neoplasms: Report of 11 Cases, Including a Case of Metaplastic Carcinoma Associated With Apocrine Poroma (Sarcomatoid Apocrine Porocarcinoma)

• DOI: 10.1097/dad.0b013e31815f2ae3
• Publication Date: 2009-03-05T06:40:16Z
• Authors: Dmitry V Kazakov; Heinz Kutzner; Dominic V Spagnolo; Werner Kempf; Bernhard Zelger; Petr Mukensnabl; Michal Michal
• Keywords: Sebaceous carcinoma; Apocrine; Sebaceous gland; Metaplastic Carcinoma

We describe 11 poroid neoplasms with sebaceous differentiation, including a metaplastic (sarcomatoid) carcinoma arising in association an apocrine poroma. Six lesions had the silhouette of classical poroma, 3 hidradenoma and 1 dermal duct tumor. In all cases, differentiation was identified as clustered or solitary, mature sebocytes occurring mainly at periphery intradermal cellular aggregations, accompanied by ducts. one clusters were seen within aggregates intraepidermally. hidradenomas, eosinophilic cuticle lining cyst crenulated foci associated sebocytes. none cases there signs follicular differentiation. One addition to showed decapitation secretion some ductular structures. The single ulcerated oval spindle cell neoplasm surrounded laterally residuum poroma containing groups epithelial islands prominently keratinized blended gradually pleomorphic cells that immunohistochemically stained focally for cytokeratins simultaneously strong vimentin expression. Our study supports previous findings can be not only but also related known tumor hidradenoma. Occurrence is rare event which indicates existence malignant counterpart latter entity, descriptively referred "sarcomatoid porocarcinoma."