Intralymphatic Histiocytosis. A Clinicopathologic Study of 16 Cases

• DOI: 10.1097/dad.0b013e3181986cc2
• Publication Date: 2009-05-21T09:49:20Z
• Authors: Luis Requena; Laila El-Shabrawi...; Sarah N Walsh; Sonia Segura; Mirjana Ziemer; Mark A Hurt; Omar P Sangüeza; Heinz Kutzner
• Keywords: CD68; Lymphatic Endothelium; CD31; Podoplanin; Reticular Dermis; Reticular connective tissue

Intralymphatic histiocytosis is a rare condition characterized by the presence of dilated lymphatic vessels containing aggregates mononuclear histiocytes (macrophages) within their lumina. The phenomenon seems to occur almost exclusively reticular dermis. Although its pathogenesis remains uncertain, there has been speculation about possible relationship between intralymphatic and intravascular reactive angioendotheliomatosis. In addition, several examples historically have associated with rheumatoid arthritis. We describe our experience 16 cases histiocytosis. Clinically, lesions were located predominantly on upper lower limbs, they consisted asymptomatic poorly demarcated erythematous plaques livedo reticularis-like lesions. They histopathologically vascular structures involving Some these had empty lumina, whereas others contained variable number histiocytes. An inflammatory response intensity from case was also present in adjacent exhibited thin walls irregular shapes, single discontinuous layer flat endothelial cells lined Immunohistochemically, lining lumina expressed immunoreactivity for CD31, CD34, podoplanin, D2-40, Lyve-1, Prox-1, which confirmed nature as cells. CD68 (PGM1), although some immunoexpression myeloperoxidase, podoplanin. 4 that employed double immunohistochemistry, podoplanin + (PGM1) or Lyve-1 each marker highlighted specific target unequivocally; immunoreactivity, showed immunoexpression. Our findings expand previously described morphologic immunohistochemical features discuss so-called