Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes

• DOI: 10.1097/ede.0b013e318176b8ad
• Publication Date: 2008-08-11T07:19:53Z
• Authors: Paul Knekt; Maarit Laaksonen; Catharina Mattila; Tommi Härkänen; Jukka Marniemi; Markku Heliövaara; Harri Rissanen; Jukka Montonen; Antti Reunanen
• Keywords: Quartile

Low vitamin D status has been suggested as a risk factor for type 2 diabetes. Although the epidemiologic evidence is scarce, recent studies have an association. The present study investigated relation of serum with diabetes incidence using pooled data from these cohorts.Two nested case-control studies, collected by Finnish Mobile Clinic in 1973-1980, were analysis. populations consisted men and women aged 40-74 years free at baseline. During follow-up period 22 years, 412 incident cases occurred, 986 controls selected individual matching. Serum (serum 25(OH)D) was determined frozen samples, stored Pooled estimates relationship between concentration calculated.Men had higher concentrations than showed reduced their highest quartile. relative odds lowest quartiles 0.28 (95% confidence interval = 0.10-0.81) 1.14 (0.60-2.17) after adjustment smoking, body mass index, physical activity, education.The results support hypothesis that high provides protection against Residual confounding may contribute to this