Hand, Foot, and Mouth Disease in China

• DOI: 10.1097/ede.0b013e318231d67a
• Publication Date: 2011-10-04T21:55:51Z
• Authors: Yu Wang; Zijian Feng; Yang Yang; Steve Self; Yongjun Gao; Ira M. Longini; Jon Wakefield; Jing Zhang; Liping Wang; Xi Chen; Lena Yao; Jeffrey D. Stanaway; Zijun Wang; Weizhong Yang
• Keywords: Hand-foot-and-mouth disease; Foot (prosody)

There were large outbreaks of hand, foot, and mouth disease in both 2008 2009 China.Using the national surveillance data since 2 May 2008, we summarized epidemiologic characteristics recent outbreaks. Using a susceptible-infectious-recovered transmission model, evaluated transmissibility potential risk factors.Children ages 1.0 to 2.9 years most susceptible (odds ratios [OR] >2.3 as compared with other age-groups). Infant cases had highest incidences severe (ORs >1.4) death >2.4), well longest delay from symptom onset diagnosis (2.3 days). Boys more than girls (OR = 1.56 [95% confidence interval 1.56-1.57]). A 1-day was associated increases odds by 40% (39%-42%) 54% (44%-65%). Compared Coxsackie A16, enterovirus 71 is strongly 16 [13-18]) 40 [13-127]). The estimated local effective reproductive numbers among prefectures ranged 1.4 1.6 (median 1.4) spring stayed below 1.2 seasons. higher temperatures range 70° F 80°F, relative humidity, [corrected] wind speed, precipitation, greater population density, periods during which schools open.Hand, moderately transmittable infectious disease, mainly preschool children. Enterovirus responsible for fatalities. Mixing asymptomatically infected children might have contributed spread infection. Timely may be key reducing high mortality rate infants.