Calcitonin Gene-Related Peptide-Mediated Depressor Effect and Inhibiting Vascular Hypertrophy of Rutaecarpine in Renovascular Hypertensive Rats

• DOI: 10.1097/fjc.0b013e3181579e7e
• Publication Date: 2009-03-05T03:58:30Z
• Authors: Xu-Ping Qin; Si-Yu Zeng; Dai Li; Qing-Quan Chen; Dan Luo; Zhe Zhang; Gao-Yun Hu; Han-Wu Deng; Yuan-Jian Li
• Keywords: Rutaecarpine; Mesenteric arteries; Renovascular Hypertension

Calcitonin gene-related peptide (CGRP), the predominant neurotransmitter in capsaicin-sensitive sensory nerves, is a potent vasodilator and inhibits proliferation of vascular smooth muscle cells. Previous investigations have demonstrated that hypotensive effect rutaecarpine (Rut) associated to stimulation CGRP synthesis release via activation vanilloid receptor subtype 1 (VR1) phenol-induced hypertensive rat. This study tested whether depressor inhibiting hypertrophy Rut mediated by endogenous 2-kidney, 1-clip (2K1C) rats. Systolic blood pressure (SBP) was measured tail-cuff method conscious. Mesenteric arteries were isolated for examination morphological changes. The concentration plasma expression mRNA dorsal root ganglia (DRG) measured. Chronic administration (10, 20, or 40 mg/kg/day, respectively) 4 weeks caused significantly regressed lumen diameter decreased medium thickness mesenteric rats concomitantly with an increase DRG. In conclusion, chronic can reduce relieve artery 2K1C rats, effects may be related release.