Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans

• DOI: 10.1097/fpc.0b013e32834282b8
• Publication Date: 2011-02-08T06:19:41Z
• Authors: Hye-Ryun Kang; Young Koo Jee; Yon-Soo Kim; Chang Hwa Lee; Jae-Woo Jung; Sae Hoon Kim; Heung-Woo Park; Yoon-Seok Chang; In-Jin Jang; Sang-Heon Cho; Kyung-Up Min; Sang-Heon Kim; Kyung Wha Lee
• Keywords: Allopurinol; Toxic Epidermal Necrolysis; Genetic predisposition

Recent investigations suggest genetic susceptibility of allopurinol-induced severe cutaneous adverse reactions (SCARs). However, the strength association was variable according to phenotypes and ethnic backgrounds. To explore markers for SCARs in Koreans, we genotyped human leukocyte antigen (HLA) class I alleles 25 cases (20 drug-induced hypersensitivity syndrome five Stevens–Johnson syndrome/toxic epidermal necrolysis) 57 patients tolerant allopurinol. Frequencies B*5801 [92.0 vs. 10.5%, Pc=2.45×10−11, odds ratio (OR)=97.8], Cw*0302 (92.0 12.3%, Pc=9.39×10−11, OR=82.1), A*3303 (88.0 26.3%, Pc=3.31×10−6, OR=20.5) were significantly higher compared with controls. In contrast, A*0201 not found despite relatively high frequency controls (29.8%). We strong positive HLA-B*5801 negative HLA-A*0201 development Korean population.