Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms

• DOI: 10.1097/gme.0b013e3181ace49b
• Publication Date: 2009-11-05T08:18:16Z
• Authors: Stacie E. Geller; Lee P. Shulman; Richard B. van Br...; Suzanne Banuvar; Ying Zhou; Geena Epstein; Samad Hedayat; Dejan Nikolic; Elizabeth C. Krause; Colleen E. Piersen; Judy L. Bolton; Guido F. Pauli; Norman R. Farnsworth
• Keywords: Black cohosh; Vasomotor; Red Clover

In Brief Objective: The aim of this study was to evaluate the safety and efficacy black cohosh red clover compared with placebo for relief menopausal vasomotor symptoms. Methods: This a randomized, four-arm, double-blind clinical trial standardized cohosh, clover, placebo, 0.625 mg conjugated equine estrogens plus 2.5 medroxyprogesterone acetate (CEE/MPA; n = 89). Primary outcome measures were reduction in symptoms (hot flashes night sweats) by placebo; secondary outcomes included evaluation, somatic symptoms, sexual dysfunction, overall improvement quality life. Results: Reductions number after 12-month intervention as follows: (34%), (57%), (63%), CEE/MPA (94%), only differing significantly from placebo. Black did not reduce frequency Secondary indicated that both botanicals safe administered. general, there no improvements other Conclusions: Compared Safety monitoring chemically biologically extracts during daily administration 12 months. Both are widely used over-the-counter botanical treatments phase II trial,