High-sugar diets increase cardiac dysfunction and mortality in hypertension compared to low-carbohydrate or high-starch diets

• DOI: 10.1097/hjh.0b013e3283007dda
• Publication Date: 2008-06-09T07:12:50Z
• Authors: Naveen Sharma; Isidore C Okere; Brian R Barrows; Biao Lei; Monika K Duda; Celvie L Yuan; Stephen F Previs; Victor G Sharov; Agnes M Azimzadeh; Paul Ernsberger; Brian D Hoit; Hani Sabbah; William C Stanley
• Keywords: Dietary Sucrose

Sugar consumption affects insulin release and, in hypertension, may stimulate cardiac signaling mechanisms that accelerate left ventricular hypertrophy and the development of heart failure. We investigated effects high-fructose or sucrose diets on function mortality hypertensive Dahl salt-sensitive rats.Rats were fed chows either high starch (70% starch, 10% fat by energy), (20% carbohydrates, 60% fat), fructose (61% fructose, 9% sucrose, fat). Hypertension was induced adding 6% salt to chow (n = 8-11/group).After 8 weeks treatment, systolic blood pressure mass similarly increased all rats high-salt diets. caused a switch mRNA myosin heavy chain isoform from alpha beta, this effect greater groups than groups. The for atrial natriuretic factor also compared respective controls, with increase being significantly group. Mortality group (44%) other (12-18%), as cardiomyocyte apoptosis. Left ejection fraction lower group, which due an end-systolic volume, not end-diastolic volume.Diets sugar accelerated dysfunction hypertension low-carbohydrate/high-fat high-starch diet.