Effect of mineralocorticoid receptor blockade on the renal renin–angiotensin system in Dahl salt-sensitive hypertensive rats

• DOI: 10.1097/hjh.0b013e328325d861
• Publication Date: 2009-05-21T13:09:43Z
• Authors: Aoshuang Zhu; Takashi Yoneda; Masashi Demura; Shigehiro Karashima; Mikiya Usukura; Masakazu Yamagishi; Yoshiyu Takeda
• Keywords: Plasma renin activity; Mineralocorticoid

The (pro)renin receptor exists in the kidney, blood vessels and heart. (Pro)renin binds to induces tissue injuries directly, completely independent of angiotensin II (Ang II). renal renin-angiotensin-aldosterone system is activated salt-sensitive hypertensive rats with in-vitro studies showing aldosterone increases angiotensin-converting enzyme (ACE) activity, renin production type 1 (AT1R) activity. However, effect blockade mineralocorticoid on receptor, angiotensinogen, ACE AT1R Dahl unknown.The following parameters were measured salt-resistant fed high-salt or low-salt diets treated for 8 weeks without eplerenone (100 mg/kg per day, orally): pressure, plasma concentration, kidney weight Ang contents, urinary protein excretion, glomerular injury (assessed by semiquantitative morphometric analysis) levels expression messenger RNA (mRNA) AT1R.Dahl a diet had increased kidney/body (175%) excretion (886%) decreased activity concentration. developed progressive sclerotic proliferative changes, concomitant mRNA content. Treatment was associated significant improvements body ratio, scores angiotensinogen content.A high salt renin-angiotensin system, whereas receptors attenuated decreasing rats.