High-salt diet during pregnancy and angiotensin-related cardiac changes

• DOI: 10.1097/hjh.0b013e328337da8f
• Publication Date: 2010-03-23T06:43:39Z
• Authors: Yang Ding; Juanxiu Lv; Caiping Mao; Huiying Zhang; Aiqing Wang; Liyan Zhu; Hui Zhu; Zhice Xu
• Keywords: 0301 basic medicine; Angiotensins; Base Sequence; Myocardium; Blotting, Western; Body Weight; Cell Cycle; DNA Methylation; Polymerase Chain Reaction; Rats; 3. Good health; Rats, Sprague-Dawley; 03 medical and health sciences; Pregnancy; Animals; Female; Sodium Chloride, Dietary; Energy Intake; DNA Primers

High-salt intake has been demonstrated in link to hypertension, and cardiovascular diseases could be programmed fetal origins. We determined the influence of high-salt diet during pregnancy on development heart.Fetal cardiac structures, cell cycle, renin-angiotensin system (RAS), epigenetic alternations heart following maternal high salt were examined.Following exposure salt, disorganized myofibrillae mitochondria cristae loss found fetus, S-phase for cells was enhanced, plasma angiotensin II decreased, increased fetus. Angiotensin II-increased primarily via AT1 receptor mechanisms. AT2 mRNA protein not affected, whereas protein, AT1a, AT1b increased. DNA methylation at CpG sites that related receptors heart. Cardiac adult offspring also higher prenatal salt.The results suggest a relationship between developmental changes system.