Body mass index and outcome in patients with coronary, cerebrovascular, or peripheral artery disease: findings from the FRENA registry

• DOI: 10.1097/hjr.0b013e32832b1818
• Publication Date: 2009-07-29T03:30:58Z
• Authors: Raquel Barba; Josep Bisbe; José Nicolas Alca...; Jesús Toril; Rafael Monte; Juan Francisco Sá...; Manuel Monreal
• Keywords: Underweight; Obesity paradox; Stroke

Background The relationship between body mass index (BMI) and mortality in patients with established arterial disease remains controversial. Methods FRENA is an ongoing, observational registry of consecutive outpatients coronary artery (CAD), cerebrovascular disease, or peripheral (PAD). We examined the prognostic importance accepted BMI categories on outcome among registry. Results In April 2008, 2274 (mean age, 66 years) had been enrolled, whom 14 (0.6%) were underweight; 533 (23%) normal; 1051 (46%) overweight; 676 (30%) obese. Over a mean follow-up months, incidence major cardiovascular events (myocardial infarction, ischemic stroke, critical limb ischemia) per 100 patient-years was: 7.1 [95% confidence interval (CI): 0.4–35]; 11 (95% CI: 8.4–14); 6.9 5.6–8.5); 8.5 6.6–11), respectively. Their 0.4–35); 4.1 5.9–11); 1.3 0.9–2.3); 1.5 1.4–3.5), On multivariate analysis, hazard ratio for 2.2 0.3–17); 1.0 (reference); 0.37 0.20–0.69); 0.18–0.73), Survival benefit was only found CAD PAD. Weight loss little influence outcome. Conclusion Patients PAD (not those disease) have inverse correlation mortality, even after adjusting confounding variables.