RETINAL PIGMENT EPITHELIAL ATROPHY IN PATIENTS WITH EXUDATIVE AGE-RELATED MACULAR DEGENERATION UNDERGOING ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY

• DOI: 10.1097/iae.0b013e3182657fff
• Publication Date: 2012-07-28T11:59:00Z
• Authors: Noemi Lois; Vikki Mcbain; Ehab Abdelkader; Neil W. Scott; Reena Kumari
• Keywords: Degeneration (medical)

To evaluate the occurrence of retinal pigment epithelial atrophy in patients with age-related macular degeneration undergoing anti-vascular endothelial growth factor therapy.The study is a retrospective review. Eligible were and choroidal neovascular membranes treated between October 2007 February 2011; they followed for >3 months, fundus photographs fluorescein angiography at baseline autofluorescence near-infrared images follow-up. Demographics, visual acuity, type membranes, number treatments performed, length follow-up recorded. Autofluorescence evaluated presence or absence areas reduced signal. A multilevel logistic regression model was used to investigate factors that may be associated "progression atrophy" follow-up, which primary outcome this study.Sixty-three (72 eyes) median 16 months (range, 3-36 months). Atrophy observed 47% (34/72) eyes; progression occurred 62% (45/72) eyes last visit. The injections received statistically significantly (odds ratio, 1.35; 95% confidence interval, 1.05-1.73; P = 0.02).Atrophy frequently therapy.