The NEIGHBOR Consortium Primary Open-Angle Glaucoma Genome-wide Association Study

• DOI: 10.1097/ijg.0b013e31824d4fd8
• Publication Date: 2012-07-24T06:37:50Z
• Authors: Janey L. Wiggs; Michael A. Hauser; Wael Abdrabou; Robert Rand Allin...; Donald L. Budenz; Elizabeth DelBono; David S. Friedman; Jae H. Kang; Douglas Gaasterland; Terry Gaasterland; Richard K. Lee; Paul R. Lichter; Stephanie Loomis; Yutao Liu; Cathy McCarty; Felipe A. Medeiros; Sayoko E. Moroi; Lana M. Olson; Anthony Realini; Julia E. Richards; Frank W. Rozsa; Joel S. Schuman; Kuldev Singh; Joshua D. Stein; Douglas Vollrath; Robert N. Weinreb; Gadi Wollstein; Brian L. Yaspan; Sachiko Yoneyama; Don Zack; Kang Zhang; Margaret Pericak-...; Louis R. Pasquale; Jonathan L. Haines
• Keywords: Adult; Male; 0301 basic medicine; Aging; primary open-angle glaucoma; Genotype; Clinical Sciences; Trabeculectomy; Neurodegenerative; Ophthalmology & Optometry; 03 medical and health sciences; 80 and over; Genetics; Humans; genetics; Genetic Predisposition to Disease; Cooperative Behavior; Eye Disease and Disorders of Vision; Antihypertensive Agents; Intraocular Pressure; Aged; Aged, 80 and over; genome-wide association study; Gene Expression Profiling; Human Genome; Neurosciences; Glaucoma; Middle Aged; 3. Good health; Open-Angle; Research Design; Case-Control Studies; Female; Glaucoma, Open-Angle; Genome-Wide Association Study

Primary open-angle glaucoma (POAG) is a common disease with complex inheritance. The identification of genes predisposing to POAG is an important step toward the development of novel gene-based methods of diagnosis and treatment. Genome-wide association studies (GWAS) have successfully identified genes contributing to complex traits such as POAG however, such studies frequently require very large sample sizes, and thus, collaborations and consortia have been of critical importance for the GWAS approach. In this report we describe the formation of the NEIGHBOR consortium, the harmonized case control definitions used for a POAG GWAS, the clinical features of the cases and controls, and the rationale for the GWAS study design.