EFFICACY AND SAFETY OF CASPOFUNGIN FOR THE EMPIRIC MANAGEMENT OF FEVER IN NEUTROPENIC CHILDREN

• DOI: 10.1097/inf.0b013e318067b4d1
• Publication Date: 2007-08-23T07:06:27Z
• Authors: Alicia Koo; Lillian Sung; Upton Allen; Ahmed Naqvi; Jennifer Drynan-A...; Allison Dekker; Anne Marie Maloney; L Lee Dupuis
• Keywords: Concomitant

This retrospective review evaluates the response to caspofungin when given children with febrile neutropenia and describes adverse effects attributable caspofungin, including risk of hepatotoxicity during concomitant therapy cyclosporine. Sixty-seven courses administered 56 patients (1–17 years) were surveyed; 53 (79%) resulted in an overall favorable response. Ten (15% courses) experienced drug-related event that was probably or possibly caspofungin. Rash hypokalemia most commonly identified effects. One 19 receiving cyclosporine concurrently developed related