Prevalence of Human Papillomavirus in the Oral Cavity/Oropharynx in a Large Population of Children and Adolescents

• DOI: 10.1097/inf.0b013e318124a4ae
• Publication Date: 2007-08-23T07:06:27Z
• Authors: Elaine M. Smith; Sandhya Swarnavel; Justine M. Ritchie; Donghong Wang; Thomas H. Haugen; Lubomir P. Turek
• Keywords: Sex organ; Genital warts

Human papillomavirus (HPV) in the oral cavity or oropharynx is associated with an increased risk of laryngeal papillomatosis, head and neck cancer, cervical other genital cancers. We evaluated prevalence HPV DNA cavity/oropharynx a cross section children aged 2 weeks to 20 years.A factor questionnaire exfoliated cells were collected from (N = 1235). was detected using PCR, dot blot hybridization, sequencing.The 1.9% children. A bimodal age distribution observed highest youngest oldest groups: 2.5% <1 year, 0.8% 1 4 years, 1.2% 5 11 1.5% 12 15 3.3% 16 years. The quadrivalent vaccine types (HPV-6, 11, 16, 18) reached 0.9% 16- 20-year group. In this group, female gender [odds ratio (OR): 6.9, P 0.04], warts (OR: 19.3, < 0.01), current smoker 6.5, 0.01) higher being infection. No factors parents identified transmission infants.The age-specific rates large adolescents demonstrate that infection acquired gradually childhood. These data support target for vaccination before puberty prevent serious HPV-related diseases.