The Use of Dengue Nonstructural Protein 1 Antigen for the Early Diagnosis During the Febrile Stage in Patients With Dengue Infection

• DOI: 10.1097/inf.0b013e318150666d
• Publication Date: 2009-03-05T04:50:50Z
• Authors: Ampaiwan Chuansumrit; Wathanee Chaiyara...; Viroj Pongthanapi...; Kanchana Tangnara...; Sarapee Lertwongrath; Sutee Yoksan
• Keywords: Dengue hemorrhagic fever

Background: To evaluate the use of dengue nonstructural protein 1 (NS1) antigen for early diagnosis during febrile stage in patients with infection. Methods: A total 445 sera obtained from 165 [dengue fever (DF): 42, hemorrhagic (DHF) grade I: 50, II: 63, III and IV: 10] 8 other illnesses 5–15 years age, were assayed NS1 antigen, dengue-specific Ig M G antibodies. Results: The positive rates among either DF or DHF was 100% (7 7) on day 2, 92.3% (12 13) 3, 76.9% (40 52) 4, 56.5% (61 108) 5 fever; declined to 43.1% (59 137) 6 defervescence 29.8% (25 84) 7 (1 after defervescence). higher than those but no statistically significant difference found. However, primary infection had significantly secondary antibodies reverse proportion antigen. additional antibody determination increased 90.4% (47 83.3% (90 95.6% (131 defervescence, 88.1% (74 7. Conclusions: Dengue testing is suggested as a helpful tool onset fever. diagnostic rates.