Viral Coinfections in Children With Invasive Pneumococcal Disease

• DOI: 10.1097/inf.0b013e3181cdafc2
• Publication Date: 2010-03-18T09:38:32Z
• Authors: Benyachalee Techa...; Chonnamet Techasa...; Asuncion Mejías; George H. McCracken; Octavio Ramilo
• Keywords: Viral Pneumonia; Bacteremia; Viral meningitis

Respiratory viruses contribute to the seasonal pattern of invasive pneumococcal disease (IPD), but impact viral coinfections on clinical characteristics and outcomes patients with IPD have not been well defined.This study was designed describe compare presentations or without coinfections.Retrospective analyses records all children treated at Children's Medical Center Dallas (CMCD) for from July 2005 June 2008. Viral studies included direct fluorescent antibody staining culture. For comparisons, were classified in 3 groups: positive, negative, no performed.A total 129 admitted CMCD during year study; 57% male. Ages ranged 2 months 18 years (median 25 months) 48% <2 years. performed 82 (63%) patients, 28 (34%) had positive results. The most common isolated influenza (7, 25%), rhinoviruses (6, 21%), adenoviruses RSV (5, 18%). Peaks occurred February November which coincided peak numbers IPD. Of 6 adenovirus coinfection, 5 Pediatric Intensive Care Unit (PICU). serotypes 19A (41, 32.5%), 7F (14, 11%), 23A (13, 10.3%). Pneumonia (42%), bacteremia (22%), meningitis (17%) syndromes. There differences duration fever before admission, maximum temperatures hospitalization white blood cell counts, between negative studies, there a trend patient be PICU more frequently longer stay. Three who died documented (2 adenovirus, 1 parainfluenza 3), underlying conditions. other performed. Duration treatment -210 days 14), among groups.Viral Future prospective should include new PCR assays characterize better occurrence outcome