Transplacental Transport of IgG Antibodies Specific for Pertussis, Diphtheria, Tetanus, Haemophilus influenzae Type b, and Neisseria meningitidis Serogroup C Is Lower in Preterm Compared With Term Infants

• DOI: 10.1097/inf.0b013e3181dc4f77
• Publication Date: 2010-04-01T08:22:43Z
• Authors: Jolice P. van den...; Elisabeth A. M. W...; Guy A. M. Berbers; Pieter G. M. van ...; Fiona R. M. van d...; Ruurd M. van Elburg
• Keywords: Transplacental; Pertactin; Whooping cough

Maternal antibodies, transported through the placenta during pregnancy, contribute to protection of infants from infectious diseases first months life. The aim this study was measure concentration antibodies against several vaccine-preventable in paired maternal and cord blood serum samples preterm term assess placental transfer ratios infant antibody concentrations diseases.Antibody specific pertussis proteins (pertussis toxin, filamentous hemagglutinin, pertactin, fimbriae), diphtheria tetanus toxins, polysaccharides Haemophilus influenzae type b Neisseria meningitidis serogroup C were measured (<32 weeks 1500 g) samples, using a fluorescent bead-based multiplex immunoassay.A total 96 42 their mothers included study. Placental all vaccine antigens significantly lower (medians varied 0.26 0.86) compared with (medians, 0.74-1.89; P < 0.05). Furthermore, polysaccharide-vaccine-specific showed transplacental transport than protein-vaccine-specific antibodies. are most important determinants diseases.Preterm benefit lesser extent infants, posing them at higher risk for