Immunologic Outcomes of Antiretroviral Therapy Among HIV-infected Nigerian Children and Its Association With Early Infant Feeding and Nutritional Status at Treatment Initiation

• DOI: 10.1097/inf.0b013e31828b2a2f
• Publication Date: 2013-02-14T07:32:29Z
• Authors: Adetayo O. Omoni; Parul S. Christian; Wilson E. Sadoh; Adaora Okechukwu; Eyinade Olateju; Austin Omoigberale; William Blattner; Man E. Charurat
• Keywords: Underweight

Objectives: To evaluate immunologic response to antiretroviral treatment (ART) among HIV-infected Nigerian children (<36 months old) and assess its association with early infant feeding pattern nutritional status at initiation. Design: Mixed prospective retrospective cohort study. Methods: One hundred fifty were followed for 12 from initiation of ART. CD4 count/CD4% was assessed baseline every 4–6 months. Nutritional by height-for-age, weight-for-age weight-for-height Z scores using the 2006 World Health Organization growth reference. Children classified into 4 groups—exclusively breast-fed, predominantly mixed fed exclusively formula fed. Logistic regression used model odds failure reach CD4% ≥25% 12-month follow-up. Linear random effects models longitudinal change in CD4%. Results: There a significant increase all 13.8% 28.5% after (ΔCD4% = 14.7%, 95% confidence interval: 12.1%–17.4%). no outcomes. In adjusted analyses, who underweight (weight-for-age < –2.0) or <15% 4.30 (95% 1.16, 15.87; P 0.05) times 3.41 1.10, 10.52; times, respectively, more likely not attain Conclusion: Baseline independently associated on These results emphasize importance screening ART resource-poor settings before malnutrition severe immunosuppression sets in.