The Association Study of Polymorphisms in DAT, DRD2, and COMT Genes and Acute Extrapyramidal Adverse Effects in Male Schizophrenic Patients Treated With Haloperidol

• DOI: 10.1097/jcp.0b013e31829abec9
• Publication Date: 2013-08-17T10:55:38Z
• Authors: Maja Zivković; Alma Mihaljević-P...; Nada Bozina; Marina Sagud; Matea Nikolac-Per...; Bjanka Vuksan-Cusa; Dorotea Muck-Seler
• Keywords: rs4680

Extrapyramidal symptoms (EPSs) are common adverse effects of antipsychotics. The development acute EPSs could depend on the activity dopaminergic system and its gene variants. aim this study was to determine association between type 2 receptor (DRD2) dopamine transporter (SLC6A3) catechol-O-methyltransferase (COMT) polymorphisms in 240 male schizophrenic patients treated with haloperidol (15-mg/d) over a period weeks. Acute were assessed Simpson-Angus Scale. Three polymorphisms, DRD2 Taq1A, SLC6A3 VNTR, COMT Val158Met, determined. occurred 116 (48.3%) patients. Statistically significant associations found for VNTR Val158Met EPS susceptibility. Patients 9/10 genotype had almost twice odds develop compared those all other genotypes (odds ratio, 1.9; 95% confidence interval, 1.13-3.30), Val/Met 1.7 times greater than 1.7; 1.01-2.88). There no statistically allele frequencies DRD2, SLC6A3, or particular EPSs.In conclusion, results present showed first time haloperidol-induced polymorphisms. Although precise biological mechanisms underlying these findings not yet understood, suggest that variations predict vulnerability haloperidol-treated