Aerobic Training Restores Arterial Baroreflex Sensitivity in Older Adults With Type 2 Diabetes, Hypertension, and Hypercholesterolemia

• DOI: 10.1097/jsm.0b013e3181ea8454
• Publication Date: 2010-07-03T08:39:07Z
• Authors: Kenneth M Madden; Chris Lockhart; Tiffany F Potter; Darcye Cuff
• Keywords: Aerobic Exercise

Objective: Lowered baroreflex sensitivity (BRS) predicts mortality and occurs with increasing age diabetes. We examined whether aerobic exercise could restore arterial BRS in adults at high cardiovascular risk (diabetes, geriatric group, hypercholesterolemia, hypertension). Design: Randomized, controlled, single-blind study. Setting: VITALiTY (Vancouver Initiative to Add Life Years) Research Laboratory. Participants: Thirty-nine older (mean age, 71.5 ± 0.7 years) diet-controlled or oral hypoglycemic-controlled type 2 diabetes, hypertension, hypercholesterolemia. Interventions: Subjects were recruited each of groups: an group (3 months vigorous as defined by 80% 85% maximal heart rate), a nonaerobic (no exercise) group. Exercise sessions supervised certified trainer 3 times per week. Main Outcome Measures: Baroreflex function was assessed using the spontaneous method. outcome measures included BRS, BRSup, BRSdown, V̇o2max. Results: The demonstrated increase that not (+60.9 23.5 vs +2.2 7.9%; P = 0.010). Conclusions: Our findings indicate relatively short intervention can reverse functional impairments risk.