Lichen Sclerosus

• DOI: 10.1097/lgt.0b013e31823da7e8
• Publication Date: 2012-01-18T09:45:44Z
• Authors: Gary Ventolini; Krista M. Swenson; Michael L. Galloway
• Keywords: Adult; Databases, Factual; Administration, Topical; Injections, Subcutaneous; Drug Administration Schedule; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Recurrence; Medical Specialties; Medicine and Health Sciences; Humans; Anesthetics, Local; Glucocorticoids; Retrospective Studies; Dose-Response Relationship, Drug; Obstetrics and Gynecology; Lidocaine; Middle Aged; Prilocaine; 3. Good health; Lichen Sclerosus et Atrophicus; Patient Satisfaction; Drug Therapy, Combination; Female; Follow-Up Studies

The purpose of our study was to compare clinical data regarding patients with pruritic lichen sclerosus (LS) at moderate or severe stages using 2 different therapies with a 5-year follow-up.The study was approved by the institutional review board and was presented as a retrospective clinical data review of patients with pruritic biopsy diagnosis LS who underwent therapy at our university private practice from 2002 to 2005. We compared the results of a weekly topical application of high-potency steroid (HPS) with a combined HPS and monthly anesthetic/steroid subdermal injection (ASI). Outcomes were timed to achieve pruritus-free status, the number of symptomatic recurrences, and patient satisfaction with therapy.Fifty-four patients were diagnosed with LS between 2002 and 2005. There were 13 patients who had mild-stage, 25 who had moderate-stage, and 16 who had severe-stage LS. Five-year follow-up data on 17 patients with moderate-stage LS and 14 patients with severe-stage LS were obtained. Time to pruritus free was 6 weeks with ASI and 19 weeks with HPS for moderate-stage LS (p = .04) and 9 weeks with ASI and 24 weeks with HPS for severe-stage LS (p = .03). Recurrences were more frequent on HPS for moderate-stage LS (p = .04) but not significant with HPS for severe-stage LS (p = .15). Only ASI was successful at treating patients with recalcitrant pruritus.In our population, patients with symptomatic moderate-stage LS seem to have a more rapid and prolonged response to ASI than to HPS but are less satisfied with the injections.