Progression and Persistence of Low-Grade Cervical Squamous Intraepithelial Lesions in Women Living With Human Immunodeficiency Virus

• DOI: 10.1097/lgt.0b013e3182403d18
• Publication Date: 2012-03-29T09:19:46Z
• Authors: Michèle Desiré Zeier; Matthys Hendrik B...; Frederick Haynes ...; Ingrid Eshun-Wilson; Marije van Schalkwyk; Marina la Grange; Deidre Mason; Mercia Louw; Jean B. Nachega
• Keywords: Persistence (discontinuity)

This study aimed to investigate the progression and persistence of low-grade squamous intraepithelial lesions (SILs) in human immunodeficiency virus (HIV)-infected women.Study participants for this retrospective cohort were 1,720 women who had LSIL as their first abnormal Pap smear. A comparison survival without high-grade SIL progression-free time clearance lesion was done HIV-positive, HIV-negative, or unknown status using Kaplan-Meier method. Multivariable Cox proportional hazards regression model applied identify independent risk factors disease persistence.We found not different between HIV groups but that occurred more HIV-positive (63.8% vs 35.0%, p < .001). For group, antiretroviral therapy started before associated with decreased compared no (hazard ratio = 0.66, 95% CI 0.54-0.81, Antiretroviral also improved when corrected excision treatment age 1.71, 1.29-2.27, Excision reduced progression. In HIV-negative women, from 54.7% 0.0% (p .001), 46.9% 6.4% 39.5% 7.1% effect smaller (from 66.3% 45.5%, .001).Antiretroviral HIV-infected women.