Neutrophil-to-Lymphocyte Ratio as a New, Quick, and Reliable Indicator for Predicting Diagnosis and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss

• DOI: 10.1097/mao.0b013e31829b57df
• Publication Date: 2013-08-29T13:12:18Z
• Authors: Sahin Ulu; Memnune Sena Ulu; Abdulkadir Bucak; Ahmet Ahsen; Fatih Yucedag; Abdullah Aycicek
• Keywords: Adult; Male; Neutrophils; Hearing Loss, Sensorineural; Anti-Inflammatory Agents; Cell Count; Hearing Loss, Sudden; Middle Aged; Prognosis; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Humans; Prednisone; Female; Lymphocytes; Aged; Retrospective Studies

Idiopathic Sudden sensorineural hearing loss (ISSNHL) is a common otologic emergency. Recently, the cause of ISSNHL, which still unclear, has been focused on chronic inflammation. Neutrophil-to-lymphocyte ratio (NLR) new and quick inflammatory marker, being measured routinely in CBC tests without any cost. We aimed to investigate relationship between ISSNHL inflammation by using NLR.Forty-seven patients diagnosed with 45 age- sex-matched healthy subjects were enrolled study. An automated blood cell counter was used for NLR measurements. The assessments carried out an audiometer, audiometric patterns assessed initially after 1 month treatment. All treated prednisone dose mg/kg per day, progressive reduction maintained at least 2 weeks. Then, divided into groups as " recovered" "unrecovered" according their response treatment.The mean NLR, neutrophil, lymphocyte values significantly higher than control group (p < 0.001, p = 0.004, respectively). In addition, levels unrecovered compared recovered ones 0.001).This first study investigating its prognosis. While evaluating determining should not be overlooked reliable indicator predicting diagnosis prognosis disease.