Neutrophil-to-Lymphocyte Ratio as a New, Quick, and Reliable Indicator for Predicting Diagnosis and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss

• DOI: 10.1097/mao.0b013e31829b57df
• Publication Date: 2013-08-29T13:12:18Z
• Authors: Sahin Ulu; Memnune Sena Ulu; Abdulkadir Bucak; Ahmet Ahsen; Fatih Yucedag; Abdullah Aycicek
• Keywords: Adult; Male; Neutrophils; Hearing Loss, Sensorineural; Anti-Inflammatory Agents; Cell Count; Hearing Loss, Sudden; Middle Aged; Prognosis; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Humans; Prednisone; Female; Lymphocytes; Aged; Retrospective Studies

Idiopathic Sudden sensorineural hearing loss (ISSNHL) is a common otologic emergency. Recently, the cause of ISSNHL, which is still unclear, has been focused on chronic inflammation. Neutrophil-to-lymphocyte ratio (NLR) is a new and quick inflammatory marker, which is being measured routinely in CBC tests without any cost. We aimed to investigate the relationship between ISSNHL and inflammation by using NLR.Forty-seven patients diagnosed with ISSNHL and 45 age- and sex-matched healthy subjects were enrolled in the study. An automated blood cell counter was used for NLR measurements. The hearing assessments of the patients were carried out by an audiometer, and audiometric patterns were assessed initially and after 1 month of the treatment. All the patients were treated with prednisone in the dose of 1 mg/kg per day, with a progressive dose reduction maintained for at least 2 weeks. Then, the patients were divided into 2 groups as " recovered" and "unrecovered" according to their response to the treatment.The mean NLR, neutrophil, and lymphocyte values in patients with ISSNHL were significantly higher than the control group (p < 0.001, p < 0.001, and p = 0.004, respectively). In addition, NLR levels were higher in unrecovered patients compared with the recovered ones (p < 0.001).This is the first study investigating the relationship between NLR levels and ISSNHL and its prognosis. While evaluating ISSNHL, determining NLR should not be overlooked as a quick and reliable indicator for predicting the diagnosis and the prognosis of the disease.