In Vivo Experimental Testing of the FW Axial Blood Pump for Left Ventricular Support in Fu Wai Hospital

• DOI: 10.1097/mat.0b013e31818f592f
• Publication Date: 2008-12-17T08:15:03Z
• Authors: Yan Zhang; Sheng-Shou Hu; Jian-Ye Zhou; Han-Song Sun; Yue Tang; Hao Zhang; Zhe Zheng; Guo-Rong Li; Xiao-Dong Zhu; Xin-Min Gui
• Keywords: Descending aorta

A fully implantable, axial flow blood pump has been developed in Fu Wai Hospital aiming for clinical use. This ventricular assist device (VAD), which was after numerous CFD analyses the characteristics of pump, is 58.5-mm long, 30-mm wide (including DC motor), and weighs 240 g. The can deliver 5 L/min pressures 100 mm Hg over 8,000 rpm. In this study, short-term hemocompatibility effects left (LVAD) (FW pump) were evaluated four healthy sheep. implanted into apex beating hearts. outflow graft each anastomosed to descending aorta. hemolysis, vivo by free hemoglobin value, below 30 mg/dL. Evaluation serum biochemical data showed that implantation FW sheep with normal hearts did not impair end organ function. Gross microscopic sections kidney, liver, lung revealed no evidence microemboli. Performance considered sufficient a LVAD, although further design improvement necessary terms hemolysis antithrombosis improve biocompatibility pump.