Evaluation of Eulerian and Lagrangian Models for Hemolysis Estimation

• DOI: 10.1097/mat.0b013e318254833b
• Publication Date: 2012-05-25T18:37:41Z
• Authors: M. Ertan Taskin; Katharine H. Fraser; Tao Zhang; Changfu Wu; Bartley P. Griffith; Zhongjun J. Wu
• Keywords: Erythrocytes; Hemodynamics; Models, Cardiovascular; Equipment Design; Models, Theoretical; Blood Physiological Phenomena; Hemolysis; 03 medical and health sciences; 0302 clinical medicine; Heart Valve Prosthesis; Humans; Regression Analysis; Computer Simulation; Heart-Assist Devices; Stress, Mechanical; Shear Strength

Hemolysis caused by flow-induced mechanical damage to red blood cells is still a problem in medical devices such as ventricular assist (VADs), artificial lungs, and heart valves. A number of different models have been proposed research groups for calculating the hemolysis, these, power law-based (HI(%)=Ct(α)τ(β)) proved most popular because their ease use applicability wide range devices. However, within this law category there are implementations. The aim work was evaluate hemolysis specifically designed shearing device clinical VAD, comparing estimated results with experimental measurements these two Both Eulerian scalar transport all Lagrangian had fairly large percentage errors compared experiments (minimum 91% minimum 57%) showing they could not accurately predict magnitude hemolysis. approach correlation coefficients (>0.99) that method can relative which would be useful comparative analysis, example, ranking or design optimization studies.