Aspirin-resistant platelet aggregation in a cohort of patients with coronary heart disease
Male
Aspirin
Platelet Aggregation
Platelet Function Tests
Drug Resistance
Thrombosis
Coronary Artery Disease
Middle Aged
3. Good health
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Prevalence
Humans
Female
Platelet Aggregation Inhibitors
Aged
Monitoring, Physiologic
DOI:
10.1097/mbc.0b013e32814db7e7
Publication Date:
2007-06-20T08:09:31Z
AUTHORS (9)
ABSTRACT
Aspirin resistance could be defined as thrombotic and embolic cardiovascular events despite regular aspirin therapy. The study aimed to determine the profile prevalence of in coronary artery disease patients. We evaluated a cohort 505 patients with diagnosis taking 80–300 mg daily. Platelet functions were analyzed by Function Analyzer (PFA)-100 collagen epinephrine cartridges ADP cartridges. A closure time 186 s or less cartridge was resistance. Of patients, 118 (23.4%) resistant PFA-100. Aspirin-resistant more likely older than aspirin-sensitive (P = 0.024). No statistically significant differences between aspirin-resistant individuals present gender, major risk factors disease, number localization involved vessels, serum lipid levels, blood counts. According high heart many people are affected resistance, which may play role adverse events. Monitoring platelet function support optimization antiplatelet therapy additional and/or alternative agents.
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