Factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase polymorphism C677T are not associated with coronary artery disease and type 2 diabetes mellitus in western Iran

• DOI: 10.1097/mbc.0b013e3283255487
• Publication Date: 2009-05-21T10:22:32Z
• Authors: Zohreh Rahimi; Hamid Nomani; Hadi Mozafari; Asad Vaisi-Raygani; Hamid Madani; Shohreh Malek-Kho...; Abbas Parsian
• Keywords: Prothrombin G20210A

There are controversial results related to the contribution of factor V Leiden G1691A, prothrombin gene G20210A and methylentetrahydrofolate reductase (MTHFR) C677T mutations in development coronary artery disease (CAD) their association with diabetes. To assess distribution these thrombophilic CAD patients without type 2 diabetes mellitus (T2DM), we studied 117 [65 (CAD/T2DM) 52 (CAD/ND)] 59 age-matched sex-matched healthy individuals from population western Iran. Genotyping was done by polymerase chain reaction (PCR)-restriction fragment length polymorphism using Mnl I, Hind III Hinf I for Leiden, MTHFR C677T, respectively. The prevalence variant CAD/T2DM, CAD/ND control 3.1, 1.9 0%, Factor G1691A found 4.6% 3.8% 3.4% individuals. be 49.2, 32.7 44.1% group, Our indicate that there is no significant difference between or compared controls. Although a higher observed patients, especially those diabetes, it seems variants may not considered as independent risk factors our sample. These findings discussed relation available literature.