A comparison of the mechanical, kinetic, and biochemical properties of fibrin clots formed with two different fibrin sealants

• DOI: 10.1097/mbc.0b013e32833fcbfb
• Publication Date: 2010-12-11T07:25:13Z
• Authors: William L Hickerson; Israel Nur; Roberto Meidler
• Keywords: Thromboelastography

The objective of the present study was to compare mechanical, kinetic, and biochemical properties fibrin clots produced using EVICEL Fibrin Sealant (Human) TISSEEL Sealant. stiffness/elasticity strength formed with were assessed applied mechanical force thromboelastography (TEG). factor XIII content also evaluated. Mean Young modulus tensile by significantly higher than those (P < 0.05 for both). mean time initial clot formation predefined level numerically shorter compared TISSEEL. Furthermore, maximal amplitude greater that concentration fibrinogen samples tested 9 IU/ml undetectable concentrations samples. have a much resistance stretching are more capable maintaining their structure against allows rapid development This superior resilience obtained relative may be due in large part presence XIII.