Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies

• DOI: 10.1097/mbc.0b013e328344f80f
• Publication Date: 2011-05-14T10:57:53Z
• Authors: Sarra Klai; Najiba Fekih-Mrissa; Sonia El Housaini; Naziha Kaabechi; Brahim Nsiri; Radhouen Rachdi; Nasredine Gritli
• Keywords: Hyperhomocysteinemia; Placental abruption

Our aim in this study was to investigate the association between elevated homocysteine levels and two MTHFR polymorphisms, C677T A1298C, with several pregnancy complications such as recurrent loss, preeclampsia, placental abruption intrauterine growth retardation. In 203 women different vasculopathies, we determined A1298C prevalence their relative levels. The mean plasma level significantly higher pathologic groups when compared control group. We identified carriage of polymorphism a significant risk factor for vascular-related complications. Women or have an increased vasculopathies. mutation also had positive impact on lack morbidities needs further studies.