Maternal cerebral venous thrombosis, uncommon but serious disorder, pathologic predictors and contribution of prothrombotic abnormalities

• DOI: 10.1097/mbc.0b013e32835bace4
• Publication Date: 2013-01-19T11:56:02Z
• Authors: Sarra Klai; Najiba Fekih-Mrissa; Ridha Mrissa; Radhouen Rachdi; Nasredine Gritli
• Keywords: Adult; Venous Thrombosis; Antithrombin III; DNA Mutational Analysis; Pregnancy Complications, Hematologic; Hyperhomocysteinemia; Factor V; Polymorphism, Single Nucleotide; Protein S; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Risk Factors; Humans; Female; Prothrombin; Intracranial Thrombosis; Biomarkers; Methylenetetrahydrofolate Reductase (NADPH2); Protein C

Cerebral venous thrombosis (CVT) is a rare complication during pregnancy or the puerperium. Our aim was to identify thrombotic risk profiles that predispose to maternal CVT.The study comprised 151 individuals. All participants had a thrombotic workup that included the following: genetic markers: factor V Leiden G1691A and G20210A prothrombin mutations, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms; protein assays: protein C, protein S and antithrombin; other tests: blood typing and screening for hyperhomocysteinemia. Maternal CVT has been associated with factor V Leiden, the prothrombin G20210A mutation, protein C deficiency and hyperhomocysteinemia. We also speculate that non-O blood groups and preeclampsia could be independent risk factors for CVT.