Candesartan improves impaired endothelial function in the human coronary artery

• DOI: 10.1097/mca.0b013e328351ab42
• Publication Date: 2012-02-18T03:09:42Z
• Authors: Kenji Iino; Hiroyuki Watanabe; Takako Iino; Mitsuaki Katsuta; Takashi Koyama; Toshimitsu Kosaka; Gen Terui; Hiroshi Ito
• Keywords: Candesartan; Endothelial Dysfunction; Coronary flow reserve; Coronary circulation

Background Endothelial dysfunction is closely related to cardiovascular events. Several studies have documented that angiotensin II type 1 receptor blockers (ARB) improve peripheral endothelial dysfunction. However, the effect of ARB on coronary function remains elusive. The purpose this study was ascertain beneficial effects human artery function. Methods and Results Twenty-seven patients were randomly assigned either candesartan group (n=14) or control (n=13) followed for 12 months. Coronary blood flow velocity measured in left anterior descending without stenosis using an intracoronary Doppler-tipped guide-wire. We evaluated as reserve (CFR), which defined percent change after acetylcholine infusion. At baseline, CFR both groups below 300%, implying these had After treatment with 6 months, increased significantly from 199±20 337±27% (P<0.001), whereas did not (194±32 vs. 185±41%, P=0.52). During months observation, event-free survival rate greater than a decreased (P=0.02). Moreover, (P=0.04). Conclusion Our results suggest improves arteries may prevent cardiac