Multi-b value diffusion-weighted magnetic resonance imaging and intravoxel incoherent motion modeling

• DOI: 10.1097/md.0000000000014459
• Publication Date: 2019-02-07T08:56:52Z
• Authors: Cheng-cheng Liao; Yun-ying Qin; Qi Tang; Xiao-hong Tan; Qing Ke; Yan Rong; Jian-Hong Zhong; Le-qun Li; Hong Cen
• Keywords: Adult; Male; Lymphoma; Middle Aged; Prognosis; Sensitivity and Specificity; 3. Good health; 03 medical and health sciences; Diffusion Magnetic Resonance Imaging; 0302 clinical medicine; ROC Curve; Image Interpretation, Computer-Assisted; Humans; Female; Research Article; Neoplasm Staging

Abstract The diagnostic efficiency of diffusion-weighted magnetic resonance imaging with different b-values and application of an intravoxel incoherent motion (IVIM) model for differentiating disease states of lymphoma was investigated. Thirty-six patients at initial diagnosis and 69 after chemotherapy underwent diffusion-weighted magnetic resonance imaging (DW-MRI) with multiple b-values. Analysis parameters included the apparent diffusion coefficient (ADC) for each b-value. Standard ADC, D, D∗, and f were calculated using an IVIM model. For patients at initial diagnosis, compared with aggressive lymphomas, the benign lymph nodes exhibited higher mean ADC (2.34 vs 0.66 × 10−3 mm2/s, P < .01) for b = 200 s/mm2. The AUC, sensitivity, specificity, and the cutoff value were 0.992, 96%, 100%, and 1.09 ×10−3 mm2/s, respectively. For patients who had finished chemotherapy, the f-values of IVIM for those with partial remission (PR) were higher than those of complete remission (CR) (56.22 vs 21.81%, P < .01). The AUC, sensitivity, specificity, and the cutoff value were 0.937, 94%, 82%, 42.10%, respectively. For b = 200 s/mm2, ADC values are most helpful for characterizing benign lymph nodes and malignant lymphomas. The f-value of the IVIM is most valuable in the identification of residual lesions of lymphomas after chemotherapy.