Multi-b value diffusion-weighted magnetic resonance imaging and intravoxel incoherent motion modeling
Adult
Male
Lymphoma
Middle Aged
Prognosis
Sensitivity and Specificity
3. Good health
03 medical and health sciences
Diffusion Magnetic Resonance Imaging
0302 clinical medicine
ROC Curve
Image Interpretation, Computer-Assisted
Humans
Female
Research Article
Neoplasm Staging
DOI:
10.1097/md.0000000000014459
Publication Date:
2019-02-07T08:56:52Z
AUTHORS (9)
ABSTRACT
Abstract
The diagnostic efficiency of diffusion-weighted magnetic resonance imaging with different b-values and application of an intravoxel incoherent motion (IVIM) model for differentiating disease states of lymphoma was investigated.
Thirty-six patients at initial diagnosis and 69 after chemotherapy underwent diffusion-weighted magnetic resonance imaging (DW-MRI) with multiple b-values. Analysis parameters included the apparent diffusion coefficient (ADC) for each b-value. Standard ADC, D, D∗, and f were calculated using an IVIM model.
For patients at initial diagnosis, compared with aggressive lymphomas, the benign lymph nodes exhibited higher mean ADC (2.34 vs 0.66 × 10−3 mm2/s, P < .01) for b = 200 s/mm2. The AUC, sensitivity, specificity, and the cutoff value were 0.992, 96%, 100%, and 1.09 ×10−3 mm2/s, respectively. For patients who had finished chemotherapy, the f-values of IVIM for those with partial remission (PR) were higher than those of complete remission (CR) (56.22 vs 21.81%, P < .01). The AUC, sensitivity, specificity, and the cutoff value were 0.937, 94%, 82%, 42.10%, respectively.
For b = 200 s/mm2, ADC values are most helpful for characterizing benign lymph nodes and malignant lymphomas. The f-value of the IVIM is most valuable in the identification of residual lesions of lymphomas after chemotherapy.
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