Mortality predictors in ANCA-associated vasculitis

• DOI: 10.1097/md.0000000000028305
• Publication Date: 2021-12-23T19:22:04Z
• Authors: Marilia A. Dagostin; Sergio L.O. Nunes; Samuel K. Shinjo; Rosa M.R. Pereira
• Keywords: ANCA-Associated Vasculitis

The mortality rate of patients with anti-neutrophil cytoplasm antibody -associated vasculitis (AAV) is higher than the general population. To date, no studies have evaluated factors associated unfavorable outcomes in Brazilian patients, who represent a miscegenated Our objective was to identify clinical and laboratory features AAV.One hundred twenty eight fulfilling American College Rheumatology Chapel Hill Classification Criteria followed between 2000 2018 our Outpatient Clinics were included. Data obtained from an ongoing electronic database. Patients divided into 2 groups (dead or alive 2018), disease activity (Birmingham score [BVAS]), vasculitis-related damage (VDI), parameters compared at most recent attendance last before death.Of 128 followed, 78.9% had granulomatosis polyangiitis, 16.4% eosinophilic 4.6% microscopic polyangiitis. In 2018, 78 alive, 25 died, lost contact. main cause death infection. According univariate analysis, Birmingham score, VDI, glucocorticoid dose group died. Laboratorial related creatinine, hemoglobin, erythrocyte sedimentation ratio, C-reactive protein (CRP). Logistic regression analysis showed that high creatinine levels, CRP levels independent mortality. Survival significantly decreased renal impairment.This first study use this approach performed population it index, impairment, AAV.