Effects of liver cirrhosis and patient condition on clinical outcomes in intrahepatic cholangiocarcinoma: a retrospective analysis of 156 cases in a single center

• DOI: 10.1097/meg.0000000000001036
• Publication Date: 2017-12-27T14:52:56Z
• Authors: Daniel Jesper; Sabrina G. Heyn; Barbara Schellhaas; Lukas Pfeifer; Ruediger S. Goertz; Steffen Zopf; Markus F. Neurath; Deike Strobel
• Keywords: Intrahepatic Cholangiocarcinoma

Objective The incidence of intrahepatic cholangiocarcinoma (iCCA) has been increasing over the past few decades. Liver cirrhosis is an independent risk factor for development iCCA. This study aimed to examine prognostic impact liver and patient condition on treatment Patients methods We retrospectively analyzed cases 156 patients diagnosed with iCCA between 1990 2014 in our center. were divided into subgroups depending presence severity type treatment. Clinical data, characteristics, overall survival compared these groups. Results Forty-seven (30%) had cirrhosis, predominantly Child–Pugh scores A ( n =27) B =12). median differed receiving tumor resection (34 months), chemotherapy (10 best supportive care (2 months). An Eastern Cooperative Oncology Group Performance Status score more than 1 was a predictor poor all P <0.001), cirrhosis. Resection could be performed less frequently cirrhotic (6 vs. 31 patients; =0.04). If performed, A/B did not influence survival. Cirrhosis outcome either. In chemotherapy, cancer antigen 19-9 levels above 129 U/ml associated significantly shorter (22.5 3 months, =0.0003). Conclusion underestimated. There no difference noncirrhotic compensated Patients’ general seems value Therefore, should prevent good from or chemotherapy.