Splanchnic vein thrombosis and variceal rebleeding in patients with cirrhosis

• DOI: 10.1097/meg.0b013e328357d5d4
• Publication Date: 2012-08-24T07:33:13Z
• Authors: Lucio Amitrano; Maria A. Guardasc...; Mariano Scaglione; Antonella Menchise; Rossana Martino; Francesco Manguso; Alfonso G. Lanza; Filippo Lampasi
• Keywords: Portal vein thrombosis

Objectives Splanchnic vein thrombosis (SVT) affects the short-term prognosis of acute variceal bleeding in cirrhotic patients. This study evaluated whether SVT also rebleeding rate patients included a program secondary prophylaxis after bleeding. Patients and methods A total 387 with were from January 2001 to December 2010. Band ligation was carried out every 3–4 weeks. Follow-up endoscopy at 1, 3, 6 months, Echo-Doppler, biochemical examination months. From 2005, received anticoagulation enoxaparin 200 UI/kg/day for least The therapy started eradication. Results diagnosed 41 bleeding, eight before 18 during follow-up. Variceal eradication achieved 89.2 86.6% no-SVT Rebleeding occurred 9.5 11.9% 12 Varices relapsed more frequently than (25.4 vs. 14.67%, P=0.03). rates relapse similar who or did not receive anticoagulation, but mortality significantly lower anticoagulation. Conclusion favors esophageal varices, can be effectively prevented by standard scheduled band ligations. Anticoagulation does prevent relapse. improvement survival treated needs confirmed future studies.