Temporal trends of Barrett’s oesophagus and gastro-oesophageal reflux and related oesophageal cancer over a 10-year period in England and Wales and associated proton pump inhibitor and H2RA prescriptions

• DOI: 10.1097/meg.0b013e3283595086
• Publication Date: 2012-09-30T12:13:55Z
• Authors: Kalliopi Alexandr...; Jeremy van Vlymen; Fiona Reid; Andrew Poullis; Jin-Yong Kang
• Keywords: Esophageal disease; Gastro-; Barrett's oesophagus

Introduction There is an increasing burden of gastro-oesophageal reflux disease (GORD) and Barrett's oesophagus (BO), paralleled by incidence oesophageal adenocarcinoma. Methods Using the General Practice Research Database, we derived GORD BO cancer (OC) populations, between 1996 2005. Acid suppression treatment over study period was also studied. Results were 5860 patients with 1 25 519 GORD. The increased from 0.11 to 0.24/1000 men 0.06 0.11/1000 women. diagnosed in general practice remained stable. 69 incident OCs BOs 183 occurring more than a year after diagnosis. cumulative OC 3.00/1000 patient years 0.30/1000 years. progressive decrease H2RA prescriptions 39 14.5% increase proton pump inhibitor 52 79% new diagnosis Conclusion has doubled 2005, whereas occurred 10 times commonly those Proton prescribing gradually period. These trends have significant implications for healthcare planning financing UK other countries.