Insulin resistance, serum visfatin, and adiponectin levels are associated with metabolic disorders in chronic hepatitis C virus-infected patients

• DOI: 10.1097/meg.0b013e32835fa988
• Publication Date: 2013-03-07T14:34:41Z
• Authors: Lihua Chen; Wenen Liu; Shaojuan Lai; Yanming Li; Xiangxiang Wang; Huibing Zhang
• Keywords: Adult; Male; 0301 basic medicine; Cholesterol, HDL; Cholesterol, LDL; Hepatitis C, Chronic; Middle Aged; 3. Good health; 03 medical and health sciences; Case-Control Studies; Cytokines; Humans; Female; Adiponectin; Insulin Resistance; Nicotinamide Phosphoribosyltransferase; Biomarkers; Triglycerides; Aged

The aim of this study was to determine the serum levels of visfatin, adiponectin, and insulin resistance (IR) in patients with hepatitis C virus (HCV) infection and their relations to the biochemical markers of hepatitis C.This study was carried out on 40 HCV-infected patients and 40 sex/age/BMI-matched healthy adults. Lipid profile, liver function tests, IR, serum adiponectin, and visfatin of all patients were examined. Correlations between IR, adiponectin, visfatin, and other variables were analyzed.The levels of visfatin and adiponectin were significantly lower in HCV patients compared with healthy controls. However, IR of HCV patients were higher than those of healthy controls. IR was significantly correlated to triglycerides, visfatin was closely related to low-density lipoprotein cholesterol, whereas adiponectin was associated with high-density lipoprotein cholesterol. These results suggest that IR, serum visfatin, and adiponectin levels are associated with metabolic disorders in chronic HCV-infected patients.IR, adiponectin, and visfatin were related to several metabolic markers of HCV, suggesting the characteristics of HCV-related metabolic abnormalities.