Genome-Wide Association Study of Ulcerative Colitis in Koreans Suggests Extensive Overlapping of Genetic Susceptibility With Caucasians

• DOI: 10.1097/mib.0b013e3182802ab6
• Publication Date: 2013-03-22T21:38:20Z
• Authors: Suk-Kyun Yang; Myunghee Hong; Wanting Zhao; Yusun Jung; Naeimeh Tayebi; Byong Duk Ye; Kyung-Jo Kim; Sang Hyoung Park; Inchul Lee; Hyoung Doo Shin; Hyun Sub Cheong; Lyoung Hyo Kim; Hyo-Jong Kim; Sung-Ae Jung; Daehee Kang; Hee-Shang Youn; Jianjun Liu; Kyuyoung Song
• Keywords: Genome-wide Association Study; Genetic Association; Association (psychology); Genetic predisposition

Recent genome-wide association studies and meta-analyses have identified 47 susceptibility loci for ulcerative colitis (UC) in Caucasian populations. A previous study of UC a Japanese population suggested marginal sharing between Asian We performed to identify Korean further comparative study.We analyzed 581,060 autosomal single-nucleotide polymorphisms (SNPs) 388 individuals with 739 control subjects the discovery stage. For validation, 64 suggestive SNPs were an additional 417 affected 732 subjects.Three genetic validated significant association, all previously reported Caucasians including major histocompatibility complex region (top SNP, rs9271366; P = 1.03 × 10(-18), odds ratio [OR] 2.10), 16q24.1 (rs16940186; 4.39 10(-10), OR 1.56), RNF186-OTUD3-PLA2G2E at chromosome arm 1p36.13 rs4654903 OTUD3; 7.43 10(-9), 0.64). Although failed reach statistical significance, 2 rs17085007 13q12 JAK2 9p24 after Bonferroni correction (P(corrected) 0.0016 P(corrected) 0.0056, respectively). FOS, UBE2L3, gene region, rs1297265 21q21.1 likely play role both Crohn's disease UC.Our data support biologic significance overlapping Our suggest that associations tend overlap more extensively among different ethnic groups than those disease, which shows well-established dependence on ethnicity.