A New Rapid Quantitative Test for Fecal Calprotectin Predicts Endoscopic Activity in Ulcerative Colitis

• DOI: 10.1097/mib.0b013e3182802b6e
• Publication Date: 2013-03-07T14:38:42Z
• Authors: Triana Lobatón; Francisco Rodrígu...; Alicia Lopez; Elena Sánchez; Lorena Rodríguez-...; Jordi Guardiola
• Keywords: Male; Endoscopy; Enzyme-Linked Immunosorbent Assay; Middle Aged; Prognosis; 3. Good health; Feces; 03 medical and health sciences; C-Reactive Protein; 0302 clinical medicine; Humans; Colitis, Ulcerative; Female; Prospective Studies; Leukocyte L1 Antigen Complex; Biomarkers; Follow-Up Studies

Fecal calprotectin (FC) determined by the enzyme-linked immunosorbent assay (ELISA) test has been proposed as a promising biomarker of endoscopic activity in ulcerative colitis (UC). However, data on its accuracy predicting is scarce. Besides, FC quantitative-point-of-care (FC-QPOCT) that provides rapid and individual results could optimize use clinical practice. The aims our study were to evaluate ability predict according Mayo score patients with UC when FC-QPOCT compare it ELISA (FC-ELISA).FC was simultaneously FC-ELISA undergoing colonoscopy. Clinical disease endoscopy assessed score. Blood tests taken analyze serological biomarkers.A total 146 colonoscopies performed 123 UC. correlated more closely subscore (Spearman's correlation coefficient rank r = 0.727, P < 0.001) than (r 0.636, 0.001), platelets 0.381, leucocytes 0.300, C-reactive protein 0.291, 0.002). prediction "endoscopic remission" (Mayo ≤1) (280 µg/g) (250 presented an area under curve 0.906 0.924, respectively. interclass index between both 0.904 (95% confidence interval, 0.864-0.932; 0.001).FC QPOCT accurate surrogate marker good test.