Prognostic value of volumetric parameters measured by F-18 FDG PET/CT in surgically resected non-small-cell lung cancer

• DOI: 10.1097/mnm.0b013e328351d4f5
• Publication Date: 2012-03-09T12:54:58Z
• Authors: Keunyoung Kim; Seong-Jang Kim; In-Joo Kim; Yun Seong Kim; Kyoungjune Pak; Heeyoung Kim
• Keywords: Standardized uptake value; Cut-off

The aim of this study was to evaluate the usefulness tumor burden as characterized by metabolic volume (MTV) and total lesion glycolysis (TLG) measured F-18 fluoro-2-deoxyglucose (F-18 FDG) PET-computed tomography (CT) in predicting recurrence-free survival (RFS) overall (OS) surgically resected non-small-cell lung cancer (NSCLC) patients.We retrospectively reviewed 91 patients with pathologically documented stages I-IIIA NSCLC. MTV TLG were obtained according various thresholds standard uptake value (SUV) primary using preoperative FDG PET-CT. We used comparison receiver-operating characteristic curve analysis test statistical significance differences among multiple volumetric parameters calculated SUV cutoff values. RFS OS evaluated Kaplan-Meier method Cox regression analysis.On analysis, no significant difference found SUV. Regardless thresholds, smaller lower showed longer OS. PET-CT have better predictive performance than SUVmax for recurrence death. According multivariate analyses, MTV2.5 revealed a prognostic factor RFS. Tumor size over 3 cm selected indicator OS.Volume-based may role providing information NSCLC who received surgical treatment.